Project Number 5R01AG015490-10 Agency/Funding Organization NIA Funding Year 2009 View Full Project Details for TRANSGENIC MICE; INFLAMMATION & THE ALZHEIMER PHENOTYPE Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 9. Immunity and Inflammation d. Immunotherapy - Mechanisms of Action Researcher and Organization Principal Investigator GORDON, MARCIA N Principal Investigator First Name MARCIA N Principal Investigator Last Name GORDON Awardee Organization UNIVERSITY OF SOUTH FLORIDA Awardee State Florida Contact PI Country United States Project Detail Funding Opportunity Announcement PA-07-070: RESEARCH PROJECT GRANT (PARENT R01) FY Overall Cost $301,350 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official REFOLO, LORENZO Related Resources Repository [AlzPED] Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid depositing transgenic mice [AlzPED] Adeno-Associated Viral Vector Mediated Gene Delivery of Endothelin Converting Enzyme Reduces Aβ Deposits in APP +PS-1 Transgenic Mice [AlzPED] Aβ vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. [AlzPED] Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice [AlzPED] Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. Patent Monocytes as a gene delivery vector for secreted proteins to treat Alzheimer'S disease
