Project Number 3R01AG032611-12S1 Agency/Funding Organization NIA Funding Year 2019 View Full Project Details for Research Supplement to Promote Diversity in Health-Related Research Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category C. Translational Research and Clinical Interventions 3. Drug Discovery (small molecules and biologics) b. Tau Researcher and Organization Principal Investigator SIGURDSSON, EINAR M Principal Investigator First Name EINAR M Principal Investigator Last Name SIGURDSSON Awardee Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINE Awardee State New York, N.Y. Contact PI Country United States Project Detail Funding Opportunity Announcement PA-18-906: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) FY Overall Cost $93,256 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official YANG, AUSTIN JYAN-YU Related Resources Repository [AlzPED] Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy [AlzPED] Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. [AlzPED] Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging. Patent Immunological targeting of pathological Tau proteins
