Project Number 5R01AG018379-09 Agency/Funding Organization NIA Funding Year 2008 View Full Project Details for REGULATION OF APP PATHWAY GENE PROMOTERS IN ALZHEIMER'S Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 1. Amyloid beta a. APP Structure and Function Researcher and Organization Principal Investigator LAHIRI, DEBOMOY K Principal Investigator First Name DEBOMOY Principal Investigator Last Name LAHIRI Awardee Organization JACKSON LABORATORY Awardee State Indiana Contact PI Country United States Project Detail FY Overall Cost $287,640 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official MILLER, MARILYN Related Resources Repository [AlzPED] Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease [AlzPED] GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer’s Disease [AlzPED] Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent Patent Modulation sAPP, sAAP .alpha. and BDNF levels in individuals diagnosed with FXS and ASD
