Project Number 2P01AG017586-11 Agency/Funding Organization NIA Funding Year 2011 View Full Project Details for MECHANISMS OF PATHOGENESIS Research Categorization Primary Disease / Condition Frontotemporal Dementia CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 2. Tau c. Tau-Mediated Pathogenesis (AD and ADRD) Researcher and Organization Principal Investigator LEE, VIRGINIA M Principal Investigator First Name VIRGINIA Principal Investigator Last Name LEE Awardee Organization UNIVERSITY OF PENNSYLVANIA Awardee State Pennsylvania Contact PI Country United States Project Detail FY Overall Cost $296,411 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official MILLER, MARILYN Related Resources Repository [AlzPED] Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. [AlzPED] Epothilone D Improves Microtubule Density, Axonal Integrity and Cognition in a Transgenic Mouse Model of Tauopathy [AlzPED] Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
