Project Number 5R01AG018478-10 Agency/Funding Organization NIA Funding Year 2010 View Full Project Details for FUNCTIONAL CONSEQUENCES OF VACCINATION IN AD TG MICE Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 9. Immunity and Inflammation d. Immunotherapy - Mechanisms of Action Researcher and Organization Principal Investigator MORGAN, DAVID Principal Investigator First Name DAVID Principal Investigator Last Name MORGAN Awardee Organization UNIVERSITY OF SOUTH FLORIDA Awardee State Florida Contact PI Country United States Project Detail FY Overall Cost $272,569 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official REFOLO, LORENZO Related Resources Repository [AlzPED] Adeno-Associated Viral Vector Mediated Gene Delivery of Endothelin Converting Enzyme Reduces Aβ Deposits in APP +PS-1 Transgenic Mice [AlzPED] Aβ vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. [AlzPED] Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice [AlzPED] Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.
