Project Number 5P50AG025711-04 Agency/Funding Organization NIA Funding Year 2008 View Full Project Details for ENVIRONMENTAL ENRICHMENT EFFECTS IN ALZHEIMER'S DISEASE TRANSGENIC MICE Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category C. Translational Research and Clinical Interventions 5. Non-clinical Proof of Concept for Non-Pharmacological Interventions c. Environmental Enrichment Category F. Research Resources 1. Alzheimer's Disease Centers Researcher and Organization Principal Investigator ARENDASH, GARY W Principal Investigator First Name GARY Principal Investigator Last Name ARENDASH Awardee Organization UNIVERSITY OF SOUTH FLORIDA Awardee State Florida Contact PI Country United States Project Detail FY Overall Cost $111,627 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official PHELPS, CREIGHTON H. Related Resources Repository [NIAGADS] Mayo GWAS [AlzPED] Adeno-Associated Viral Vector Mediated Gene Delivery of Endothelin Converting Enzyme Reduces Aβ Deposits in APP +PS-1 Transgenic Mice [AlzPED] Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. [AlzPED] A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice. [AlzPED] Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. [AlzPED] Intracranial Adeno-Associated Virus-Mediated Delivery of Anti-Pan Amyloid β, Amyloid β40, and Amyloid β42 Single-Chain Variable Fragments Attenuates Plaque Pathology in Amyloid Precursor Protein Mice [AlzPED] Aβ vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.