Project Number 5R37AG013956-13 Agency/Funding Organization NIA Funding Year 2008 View Full Project Details for EFFECT OF APOE ON CNS NEURONS: ROLE OF LRP Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 4. ApoE and Lipid Neurobiology a. ApoE in Abeta-Mediated AD Pathogenesis Researcher and Organization Principal Investigator HOLTZMAN, DAVID M Principal Investigator First Name DAVID Principal Investigator Last Name HOLTZMAN Awardee Organization WASHINGTON UNIVERSITY IN SAINT LOUIS Awardee State Missouri Contact PI Country United States Project Detail FY Overall Cost $287,896 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official PETANCESKA, SUZANA Related Resources Repository [AlzPED] Treatment with an Amyloid-β Antibody Ameliorates Plaque Load, Learning Deficits, and Hippocampal Long-Term Potentiation in a Mouse Model of Alzheimer’s Disease [AlzPED] A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Patent Humanized antibodies that sequester abeta peptide
