Project Number 2R01NS050895-06 Agency/Funding Organization NINDS Funding Year 2009 View Full Project Details for COMBINING AD EPITOPE VACCINE WITH INNATE IMMUNITY Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category C. Translational Research and Clinical Interventions 3. Drug Discovery (small molecules and biologics) a. Amyloid beta Researcher and Organization Principal Investigator CRIBBS, DAVID HASTINGS Principal Investigator First Name DAVID Principal Investigator Last Name CRIBBS Awardee Organization UNIVERSITY OF CALIFORNIA IRVINE Awardee State California Contact PI Country United States Project Detail Funding Opportunity Announcement PA-07-070: RESEARCH PROJECT GRANT (PARENT R01) FY Overall Cost $422,898 Funding Organization Agency/Funding Organization NINDS Funding Organization Country United States Program Official SIEBER, BETH-ANNE Related Resources Repository [AlzPED] MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice [AlzPED] Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease. [AlzPED] Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial [AlzPED] Low Concentrations of Anti-Abeta Antibodies Generated in Tg2576 Mice by DNA Epitope Vaccine Fused with 3C3d Molecular Adjuvant Do Not Affect AD Pathology [AlzPED] Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
