Project Number 5R01AG032611-14 Agency/Funding Organization NIA Funding Year 2021 View Full Project Details for Clearance and In Vivo Detection of Tau Pathology. Research Categorization Primary Disease / Condition Alzheimer's Disease Frontotemporal Dementia CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 2. Tau b. Tau Phosphorylation, Metabolism, and Assembly Researcher and Organization Principal Investigator SIGURDSSON, EINAR M Principal Investigator First Name EINAR M Principal Investigator Last Name SIGURDSSON Awardee Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINE Awardee State New York, N.Y. Contact PI Country United States Project Detail Funding Opportunity Announcement PA-16-160: NIH Research Project Grant (Parent R01) FY Overall Cost $636,762 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official YANG, AUSTIN JYAN-YU Related Resources Repository [AlzPED] Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy [AlzPED] Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. [AlzPED] Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging. Patent Immunological targeting of pathological Tau proteins
