Project Number 2R01AG044420-06 Agency/Funding Organization NIA Funding Year 2018 View Full Project Details for Characterizing neuroprotective roles for SNX27 signaling pathways in AD and DS Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 7. Circuits and Synapses c. Neurotransmitter Receptors Structure and Function Researcher and Organization Principal Investigator XU, HUAXI Principal Investigator First Name PAUL Principal Investigator Last Name GREENGARD Awardee Organization SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE Awardee State California Contact PI Country United States Project Detail FY Overall Cost $2,437,500 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official OPANASHUK, LISA A Special Initiative Special Research Focus: Down Syndrome Related Resources Repository [AlzPED] Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy