Project Number 5P01AG005119-23 Agency/Funding Organization NIA Funding Year 2011 View Full Project Details for BETA AMYLOID-INDUCED RNA OXIDATION AS A MEDIATOR OF AD PATHOGENESIS Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 8. Cell Death b. Oxidative Stress Researcher and Organization Principal Investigator MARKESBERY, WILLIAM R Principal Investigator First Name WILLIAM R Principal Investigator Last Name MARKESBERY Awardee Organization UNIVERSITY OF KENTUCKY Awardee State Kentucky Contact PI Country United States Project Detail FY Overall Cost $229,685 Funding Organization Agency/Funding Organization NIA Funding Organization Country United States Program Official REFOLO, LORENZO Related Resources Repository [AlzPED] Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. [AlzPED] Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology
