Research Project History

Awardee Organization BRIGHAM AND WOMEN'S HOSPITAL
Funding Agency/Organization NIA

Updates

Project Number FY FY Funding Amount Sub-Project Number Project Title PI / Project Leader
5P01AG015379-24 2022 $263421 8681 Administrative Core SELKOE, DENNIS J
5P01AG015379-24 2022 $486755 8682 Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase SELKOE, DENNIS J
5P01AG015379-24 2022 $471754 8683 Project 2-Abeta-Dependent and -Independent Roles of PS1 BEREZOVSKA, OKSANA
5P01AG015379-24 2022 $471754 8684 Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators TANZI, RUDOLPH EMILE
5P01AG015379-23 2021 $263421 8681 Administrative Core SELKOE, DENNIS J
5P01AG015379-23 2021 $486755 8682 Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase SELKOE, DENNIS J
5P01AG015379-23 2021 $471755 8683 Project 2-Abeta-Dependent and -Independent Roles of PS1 BEREZOVSKA, OKSANA
5P01AG015379-23 2021 $471754 8684 Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators TANZI, RUDOLPH EMILE
5P01AG015379-22 2020 $486415 8682 Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase SELKOE, DENNIS J
5P01AG015379-22 2020 $471415 8683 Project 2-Abeta-Dependent and -Independent Roles of PS1 BEREZOVSKA, OKSANA
5P01AG015379-22 2020 $471414 8684 Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators TANZI, RUDOLPH EMILE
5P01AG015379-22 2020 $263081 8681 Administrative Core SELKOE, DENNIS J
2P01AG015379-21A1 2019 $433297 8681 Administrative Core SELKOE, DENNIS J
2P01AG015379-21A1 2019 $433297 8682 Project 1: Structure-Function Relationships in Presenilin and Gamma-Secretase SELKOE, DENNIS J
2P01AG015379-21A1 2019 $433296 8683 Project 2-Abeta-Dependent and -Independent Roles of PS1 BEREZOVSKA, OKSANA
2P01AG015379-21A1 2019 $433295 8684 Project 3-Mechanistic Studies of Novel Gamma Secretase Modulators TANZI, RUDOLPH EMILE
3P01AG015379-20S1 2018 $2095236 None Presenilin Biology and the Mechanisms of Alzheimers Disease SELKOE, DENNIS J
5P01AG015379-20 2017 $145550 6614 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-20 2017 $406723 6623 EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY TANZI, RUDOLPH EMILE
5P01AG015379-20 2017 $2096690 None PRESENILIN BIOLOGY AND THE MECHANISMS OF ALZHEIMER'S DISEASE SELKOE, DENNIS J
5P01AG015379-20 2017 $426525 6626 ROLE OF PRESENILIN 1 AT THE SYNAPSE BEREZOVSKA, OKSANA
5P01AG015379-20 2017 $418739 6641 ROLE OF SYNAPTOTAGMINS IN APP PROCESSING KOVACS, DORA M
5P01AG015379-20 2017 $699153 6615 STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE SELKOE, DENNIS J
4P01AG015379-19 2016 $2096690 None PRESENILIN BIOLOGY AND THE MECHANISMS OF ALZHEIMER'S DISEASE SELKOE, DENNIS J
4P01AG015379-19 2016 $426525 6626 ROLE OF PRESENILIN 1 AT THE SYNAPSE BEREZOVSKA, OKSANA
4P01AG015379-19 2016 $418739 6641 ROLE OF SYNAPTOTAGMINS IN APP PROCESSING KOVACS, DORA M
4P01AG015379-19 2016 $699153 6615 STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE SELKOE, DENNIS J
4P01AG015379-19 2016 $145550 6614 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
4P01AG015379-19 2016 $406723 6623 EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY TANZI, RUDOLPH EMILE
5P01AG015379-18 2015 $141085 6614 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-18 2015 $394522 6623 EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY TANZI, RUDOLPH EMILE
5P01AG015379-18 2015 $2033235 None PRESENILIN BIOLOGY AND THE MECHANISMS OF ALZHEIMER'S DISEASE SELKOE, DENNIS J
5P01AG015379-18 2015 $413729 6626 ROLE OF PRESENILIN 1 AT THE SYNAPSE BEREZOVSKA, OKSANA
5P01AG015379-18 2015 $406175 6641 ROLE OF SYNAPTOTAGMINS IN APP PROCESSING KOVACS, DORA M
5P01AG015379-18 2015 $677724 6615 STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE SELKOE, DENNIS J
5P01AG015379-17 2014 $145038 6614 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-17 2014 $406723 6623 EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY TANZI, RUDOLPH EMILE
5P01AG015379-17 2014 $2093246 None PRESENILIN BIOLOGY AND THE MECHANISMS OF ALZHEIMER'S DISEASE SELKOE, DENNIS J
5P01AG015379-17 2014 $426525 6626 ROLE OF PRESENILIN 1 AT THE SYNAPSE BEREZOVSKA, OKSANA
5P01AG015379-17 2014 $418739 6641 ROLE OF SYNAPTOTAGMINS IN APP PROCESSING KOVACS, DORA M
5P01AG015379-17 2014 $696221 6615 STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE SELKOE, DENNIS J
2P01AG015379-16A1 2013 $437853 None ROLE OF SYNAPTOTAGMINS IN APP PROCESSING KOVACS, DORA M
2P01AG015379-16A1 2013 $695267 None STRUCTURE, FUNCTION AND REGULATION OF GAMMA-SECRETASE SELKOE, DENNIS J
2P01AG015379-16A1 2013 $144697 None ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
2P01AG015379-16A1 2013 $425837 None EFFECTS OF APP-SELECTIVE GSMS AND ADAMIO MUTATIONS ON Y-SECRETASE ACTIVITY TANZI, RUDOLPH EMILE
2P01AG015379-16A1 2013 $445639 None ROLE OF PRESENILIN 1 AT THE SYNAPSE BEREZOVSKA, OKSANA
5P01AG015379-15 2012 $72341 9004 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-15 2012 $171620 10 COMMON REGULATION OF BACE1 AND Y-SECRETASE SUBSTRATE PROCESSING KOVACS, DORA M
5P01AG015379-15 2012 $166476 9 GAMMA-SECRETASE COMPONENTS AND SUBSTRATE INTERACTIONS BEREZOVSKA, OKSANA
5P01AG015379-15 2012 $171619 8 GENETIC ANALYSES OF GENES IN PRESENILIN-RELATED PATHWAYS TANZI, RUDOLPH EMILE
5P01AG015379-15 2012 $1220961 None PRESENILIN BIOLOGY AND THE MECHANISMS OF ALZHEIMER'S DISEASE SELKOE, DENNIS J
5P01AG015379-15 2012 $123277 9005 REAGENTS; ELISA AND Y-SECRETASE ASSAY CORE XIA, WEIMING
5P01AG015379-15 2012 $451587 7 STRUCTURE-FUNCTION RELATIONSHIPS IN PRESENILIN/Y-SECRETASE SELKOE, DENNIS J
5P01AG015379-15 2012 $64041 9006 TRANSGENIC ANIMALS FROSCH, MATTHEW P
5P01AG015379-14 2011 $455795 9 GAMMA-SECRETASE COMPONENTS AND SUBSTRATE INTERACTIONS BEREZOVSKA, OKSANA
5P01AG015379-14 2011 $469873 8 GENETIC ANALYSES OF GENES IN PRESENILIN-RELATED PATHWAYS TANZI, RUDOLPH EMILE
5P01AG015379-14 2011 $222995 9005 REAGENTS; ELISA AND Y-SECRETASE ASSAY CORE XIA, WEIMING
5P01AG015379-14 2011 $816854 7 STRUCTURE-FUNCTION RELATIONSHIPS IN PRESENILIN/Y-SECRETASE SELKOE, DENNIS J
5P01AG015379-14 2011 $175340 9006 TRANSGENIC ANIMALS FROSCH, MATTHEW P
5P01AG015379-14 2011 $130861 9004 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-14 2011 $469879 10 COMMON REGULATION OF BACE1 AND Y-SECRETASE SUBSTRATE PROCESSING KOVACS, DORA M
5P01AG015379-13 2010 $128966 9004 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-13 2010 $463077 10 COMMON REGULATION OF BACE1 AND Y-SECRETASE SUBSTRATE PROCESSING KOVACS, DORA M
5P01AG015379-13 2010 $449196 9 GAMMA-SECRETASE COMPONENTS AND SUBSTRATE INTERACTIONS BEREZOVSKA, OKSANA
5P01AG015379-13 2010 $463079 8 GENETIC ANALYSES OF GENES IN PRESENILIN-RELATED PATHWAYS TANZI, RUDOLPH EMILE
5P01AG015379-13 2010 $219766 9005 REAGENTS; ELISA AND Y-SECRETASE ASSAY CORE XIA, WEIMING
5P01AG015379-13 2010 $805037 7 STRUCTURE-FUNCTION RELATIONSHIPS IN PRESENILIN/Y-SECRETASE SELKOE, DENNIS J
5P01AG015379-13 2010 $172800 9006 TRANSGENIC ANIMALS FROSCH, MATTHEW P
5P01AG015379-12 2009 $104085 9004 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
5P01AG015379-12 2009 $373561 10 COMMON REGULATION OF BACE1 AND Y-SECRETASE SUBSTRATE PROCESSING KOVACS, DORA M
5P01AG015379-12 2009 $362361 9 GAMMA-SECRETASE COMPONENTS AND SUBSTRATE INTERACTIONS BEREZOVSKA, OKSANA
5P01AG015379-12 2009 $373558 8 GENETIC ANALYSES OF GENES IN PRESENILIN-RELATED PATHWAYS TANZI, RUDOLPH EMILE
5P01AG015379-12 2009 $177366 9005 REAGENTS; ELISA AND Y-SECRETASE ASSAY CORE XIA, WEIMING
5P01AG015379-12 2009 $649721 7 STRUCTURE-FUNCTION RELATIONSHIPS IN PRESENILIN/Y-SECRETASE SELKOE, DENNIS J
5P01AG015379-12 2009 $139421 9006 TRANSGENIC ANIMALS FROSCH, MATTHEW P
2P01AG015379-11 2008 $101054 9004 ADMINISTRATIVE AND EDUCATIONAL CORE SELKOE, DENNIS J
2P01AG015379-11 2008 $360631 10 COMMON REGULATION OF BACE1 AND Y-SECRETASE SUBSTRATE PROCESSING KOVACS, DORA M
2P01AG015379-11 2008 $355965 9 GAMMA-SECRETASE COMPONENTS AND SUBSTRATE INTERACTIONS BEREZOVSKA, OKSANA
2P01AG015379-11 2008 $360630 8 GENETIC ANALYSES OF GENES IN PRESENILIN-RELATED PATHWAYS TANZI, RUDOLPH EMILE
2P01AG015379-11 2008 $630796 7 STRUCTURE-FUNCTION RELATIONSHIPS IN PRESENILIN/Y-SECRETASE SELKOE, DENNIS J
2P01AG015379-11 2008 $134879 9006 TRANSGENIC ANIMALS FROSCH, MATTHEW P